https://ogma.newcastle.edu.au/vital/access/ /manager/Index ${session.getAttribute("locale")} 5 Weathering of microplastics and interaction with other coexisting constituents in terrestrial and aquatic environments https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:43671 Wed 28 Sep 2022 14:55:48 AEST ]]> Configuration and singularity analysis of a parallel hip joint simulator based on the forward kinematics https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:42057 Wed 17 Aug 2022 14:33:19 AEST ]]> Suppression of endoplasmic reticulum stress-induced invasion and migration of breast cancer cells through the downregulation of heparanase https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:14383 Wed 11 Apr 2018 09:49:12 AEST ]]> Remediation of soils and sediments polluted with polycyclic aromatic hydrocarbons: To immobilize, mobilize, or degrade? https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:43940 Wed 05 Oct 2022 12:51:29 AEDT ]]> Influence of undercrossing tunnel excavation on the settlement of a metro station in Dalian https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:49068 Wed 03 May 2023 16:08:24 AEST ]]> JMJD6 is a tumorigenic factor and therapeutic target in neuroblastoma https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:45069 JMJD6 gene at 17q21-ter activates gene transcription. Here we show that JMJD6 forms protein complexes with N-Myc and BRD4, and is important for E2F2, N-Myc and c-Myc transcription. Knocking down JMJD6 reduces neuroblastoma cell proliferation and survival in vitro and tumor progression in mice, and high levels of JMJD6 expression in human neuroblastoma tissues independently predict poor patient prognosis. In addition, JMJD6 gene is associated with transcriptional super-enhancers. Combination therapy with the CDK7/super-enhancer inhibitor THZ1 and the histone deacetylase inhibitor panobinostat synergistically reduces JMJD6, E2F2, N-Myc, c-Myc expression, induces apoptosis in vitro and leads to neuroblastoma tumor regression in mice, which are significantly reversed by forced JMJD6 over-expression. Our findings therefore identify JMJD6 as a neuroblastoma tumorigenesis factor, and the combination therapy as a treatment strategy.]]> Thu 27 Oct 2022 14:03:24 AEDT ]]> Silver nanoparticles in aquatic sediments: Occurrence, chemical transformations, toxicity, and analytical methods https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:48853 Thu 13 Apr 2023 09:52:55 AEST ]]> Distribution, behaviour, bioavailability and remediation of poly- and per-fluoroalkyl substances (PFAS) in solid biowastes and biowaste-treated soil https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:38586 Thu 11 Nov 2021 13:58:36 AEDT ]]> Down-regulation of RIP1 by 2-deoxy-D-glucose sensitizes breast cancer cells to TRAIL-induced apoptosis https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:17365 Sat 24 Mar 2018 08:01:31 AEDT ]]> Down-regulating annexin gene GhAnn2 inhibits cotton fiber elongation and decreases Ca²⁺ influx at the cell apex https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:20594 Sat 24 Mar 2018 07:55:32 AEDT ]]> Environmental fate, toxicity and risk management strategies of nanoplastics in the environment: current status and future perspectives https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:38276 Mon 29 Jan 2024 18:51:39 AEDT ]]> What have we known so far for fluorescence staining and quantification of microplastics: A tutorial review https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:48945 Mon 17 Apr 2023 16:50:19 AEST ]]> A review of microplastics aggregation in aquatic environment: influence factors, analytical methods, and environmental implications https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:46355 Fri 18 Nov 2022 10:08:39 AEDT ]]>